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  • Zoloft

  • Soheyla Talebimarani

    May 25, 2021 at 12:08 am

    My patient was taking Zoloft 100 mg, which was helpful for Anxiety and depression. she was worried regard memory impairment and asking another Medication with no memory impairment. What is your input about this issue. Thabks

  • Dr. Harvinder Singh

    May 25, 2021 at 9:29 am

    Hi Soheyla. I have not seen memory impairment with zoloft (sertraline) before. What is your patient’s age and any medical causes for memory impairment?

    I educate patients that untreated depression and anxiety can cause memory impairment (pseudo-dementia): so these medications should improve memory by improving underlying depression and anxiety.

  • Soheyla Talebimarani

    May 27, 2021 at 10:46 pm

    Thank you. She is 51 years old.

  • Gary Graham

    June 6, 2021 at 5:53 am

    I have seen issues with word-finding in the past with several antidepressants. I usually do not change the medications since when we deprescribe, the issues with memory diminish and stop on their own. Here is a case study of issues with word-finding

    I usually have a risk-benefit discussion with the client. Most prefer to stay on the medication rather than take the risk that the depression or anxiety will return. Of course, I document this conversation and assess memory issues after having it on each follow up

  • Gary Graham

    June 6, 2021 at 5:54 am

    BTW I take Zoloft myself and experience some degree of word-finding impairment I am ok with it because it is so much better than the anxiety

  • Dr. Harvinder Singh

    June 6, 2021 at 10:29 am

    Thanks @Gary Graham for your insight. You are correct and I was not aware of this as a common side effect with antidepressants.

    This cross-sectional study published in 2006 answered this question: J Clin Psychiatry. 2006 Nov;67(11):1754-9. (PMID: 17196056):

    Inclusion Criteria for this study:

    • 18+ years of age
    • Responders to antidepressant therapy following at least 3 months of treatment.
    • MDD in partial or full remission

    Study participants were administered:

    • Harvard Department of Psychiatry/National Depression Screening Day (HANDS) scale
    • Epworth Sleepiness Scale
    • Brief Fatigue Inventory
    • Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (CPFQ)
    • Study-specific questionnaire inquiring about the emergence of specific side effects such as apathy, fatigue, and inattentiveness.

    Following Cognitive symptoms were reported by >30% of the responders on antidepressants (on CPFQ & study-specific questionnaire):

    • Apathy
    • Inattentiveness
    • Forgetfulness
    • Word-finding difficulty, and
    • Mental slowing)

    Also, they found a significant, positive relationship between the CPFQ and the severity of residual depressive symptoms as measured by the HANDS total score (F = 15.3, p = .0002).


    • these symptoms are both side effects of the antidepressants as well as residual symptoms of MDD.
  • Soheyla Talebimarani

    June 7, 2021 at 8:14 am

    I appreciate it your insight and great discussion.

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Original Post
0 of 0 posts June 2018