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Psychiatry Education Forum Academy Forums General Discussions Antidepressants and hyperprolactinemia

  • Antidepressants and hyperprolactinemia

  • Allen Dsouza

    May 3, 2021 at 8:40 pm

    Has anyone had patients experience hyperprolactinemia on antidepressants especially Zoloft? Any literature on this? One of patient’s primary blames the hyperprolactinemia on Zoloft which is rarely heard of.

  • Carissa Kajenski

    May 4, 2021 at 7:05 am

    I had this happen twice. First time PCP requested I lower Zoloft (prolactin when down), second time, the PCP added cabergoline 0.5 mg QD to her medication regimen; prolactin level decreased.

  • Dr. Harvinder Singh

    May 4, 2021 at 10:29 am

    Literature review found highest incidence of SSRI associated hyperprolactinemia for:-

    Sertraline > Fluoxetine > Paroxetine > Fluvoxamine

    Note that Sertraline has the strongest dopamine reuptake blocker among SSRIs.

    Read more details in our academy chapter below.

    Antidepressants & High Prolactin:

    (Read references at the end of this chapter for more details)

    Antidepressants & High Prolactin

  • Allen Dsouza

    May 4, 2021 at 11:21 am

    Thank you so much that helps!

    • Dr. Harvinder Singh

      May 4, 2021 at 11:57 am

      Please do not hesitate in posting similar clinically relevant questions in future. This will help everyone in the academy.

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