Do SSRIs have Active Metabolite?
References:
- Fuller RW, Snoddy HD, Krushinski JH, Robertson DW. Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo. Neuropharmacology. 1992 Oct;31(10):997-1000. (PubMed PMID: 1279447)
- Sprouse J, Clarke T, Reynolds L, Heym J, Rollema H. Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo. Neuropsychopharmacology. 1996 Apr;14(4):225-31. (PubMed PMID: 8924190)
- von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Duan SX, Fogelman SM, Harmatz JS, Shader RI. Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects. Biol Psychiatry. 1999 Sep 15;46(6):839-49. (PubMed PMID: 10494454)
- Rao N. The clinical pharmacokinetics of escitalopram. Clin Pharmacokinet. 2007;46(4):281-90. Review. (PubMed PMID: 17375980)
- D.A. Ciraulo and R.I. Shader (eds.), Pharmacotherapy of Depression.
FOR PHYSICIAN’S GUIDE FOR CLINICAL PSYCHIATRY SUBSCRIBERS:
Read the following chapter discussing the therapeutic drug monitoring of antidepressants:
Therapeutic Drug Monitoring of Antidepressants.
This chapter is summarized in the following eight sections:
- SSRIs (Selective Serotonin Reuptake Inhibitors).
- SNRIs (Serotonin Norepinephrine Reuptake Inhibitors).
- NDRI (Norepinephrine Dopamine Reuptake Inhibitors).
- NaSSAs (Noradrenergics & Specific Serotonergics).
- Serotonin Modulators.
- NRI (Norepinephrine Reuptake Inhibitors).
- TCA (TriCyclic Antidepressants).
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