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  • Treatment-Resistant MDD: Modafinil Augmentation
    Partial response, no response, or residual symptoms following antidepressant therapy is common in clinical psychiatry. Hence, it is of clinical importance to have knowledge of…
  • Safest Antidepressant with Warfarin?
    Answer: (b) Sertraline. Warfarin has two isomers: S-isomer (three times more potent than R-isomer): metabolized by 2C9. R-isomer: metabolized by 1A2 (major) and 2C19 & 3A4 (minor) —> monitor…
  • How to use Pramipexole for Bipolar Depression?
    Pramipexole is currently only FDA approved for Parkinson’s disease & Moderate-to-severe primary Restless Legs Syndrome but Pramipexole has promising data as an augmentation option for…
  • Emotional Blunting with Antidepressants Versus Anhedonia from MDD?
    Antidepressants are well known to cause this side effects of emotional blunting. It is clinically relevant to diagnose this early in the treatment as this…

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