Treatment Resistant Depression with Atypical Features Management

Depression with atypical features is defined as significant mood reactivity combined with two of the following clinical features:

  • Hyperphagia
  • Hypersomnia
  • Leaden paralysis
  • Pathological rejection sensitivity

Most patients with atypical depression will respond to the trial of SSRIs or bupropion, but what are your next options if patient fails both of these trials? 

The most recent update posted by The Psychopharmacology Algorithm Project on the management of Unipolar Nonpsychotic Depression will answer this question:

We have summarized this article in our following journal club discussion:

Journal Club Discussion:

The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Unipolar Nonpsychotic Depression.

Article: Harv Rev Psychiatry. 2019 Jan/Feb;27(1):33-52. PMID: 30614886.

This 45 minutes journal club video discussion will answer the following 11 clinically relevant questions:

  1. Which medications are first-line treatment options in the management of MDD [in outpatient setting]? 
  2. What are the next step options after the first-line treatment fails (poor or no response): Augmentation options?
  3. What are the next step options after the first-line treatment fails (poor or no response): Switching options?
  4. Management options for Treatment-Resistant Depression without comorbidities.
  5. Management options for Treatment-Resistant Depression with and without Atypical Features.
  6. Management options for Treatment-Resistant Depression with Medical Comorbidities.
  7. Management options for Treatment-Resistant Depression with Chronic Pain.
  8. Management options for Treatment-Resistant Depression with OCD.
  9. Management options for Treatment-Resistant Depression with ADHD.
  10. Management options for Treatment-Resistant Depression with PTSD.
  11. How to manage Severe Melancholic Depression [in Inpatient Settings]?

FOR PEFA MEMBERS ONLY:

Psychiatry Education Forum’s Journal Club is an additional feature for PEF Academy’s members. All academy members will be automatically enrolled in this journal club.

Here we post the most recently published psychiatry articles relevant to your daily clinical practice with CME credits available for selective journal club activities. 

INTERESTED IN JOINING THIS JOURNAL CLUB DISCUSSION SERIES?

JOIN PSYCHIATRY EDUCATION FORUM ACADEMY MEMBERSHIP

This is a closed membership for medical professionals only.

  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
  • Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
  • Conference Discounts: Academy members get discounted access at our conferences. 
  • Goal: is to have all important clinically relevant topics in one place for ease of access.
 

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