Antipsychotics Induced Weight Gain


Weight gain is one of the untoward side effect of antipsychotic medications and the extent of weight gain varies among all antipsychotics. This post will briefly summarize the results of following two studies.

 


STUDY#1:

Allison et al published this comprehensive research synthesis to estimate and compare the effects of antipsychotics — both the newer ones and the conventional ones — on body weight. 

 

Weight gain was estimated at 10 weeks and antipsychotics were ranked as follows:

 

ANTIPSYCHOTICS MEAN ESTIMATED WEIGHT CHANGE AT 10 WEEKS 

CLOZAPINE

3.99 Kg

OLANZAPINE

3.51 Kg

THIORIDAZINE

3.49 Kg

CHLORPROMAZINE

2.10 Kg

RISPERIDONE

2.00 Kg

HALOPERIDOL

0.48 Kg

FLUPHENAZINE

0.43 Kg

ZIPRASIDONE

0.04 Kg

MOLINDONE

-0.81 Kg

Insufficient data were available to evaluate quetiapine at 10 weeks. 

 


STUDY#2:

This second study was meta-analysis of clinical trials of antipsychotics that reported weight change.

 

ANTIPSYCHOTICS RELATED

MEAN ESTIMATED WEIGHT CHANGE (Kg) <6 WEEKS 

(FROM HIGH TO LOW) 

CLOZAPINE

OLANZAPINE

CHLORPROMAZINE

RISPERIDONE

QUETIAPINE

ASENAPINE

PALIPERIDONE

ZIPRASIDONE

HALOPERIDOL

ARIPIPRAZOLE

 AMISULPRIDE

 


SOURCE:
  • Am J Psychiatry 1999; 156:1686–1696.
  • PLoS One. 2014 Apr 24;9(4):e94112.

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Dr. Harvinder Singh, M.D. (Admin)


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Responses

  1. In practice there is significant weight gain with Amisulpiride too

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