Antipsychotic induced Weight Gain Management: METFORMIN

This clinical topic will be summarized in the following 9 sections:

  1. Does metformin have role in the prevention and treatment of antipsychotic induced weight gain
  2. Does metformin have role in the treatment of antipsychotic induced dyslipidemia
  3. Does metformin have effect on weight gain associated with antipsychotics use in children and adolescents with autism spectrum disorders
  4. How is metformin dosed: starting dose & dose titration. 
  5. What dose of metformin is found effective in treatment of antipsychotic induced weight gain?
  6. Precautions with metformin use: When to discontinue metformin treatment? 
  7. Contraindication for metformin use. 
  8. Laboratory monitoring with metformin use.
  9. Common adverse events associated with metformin.

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Pharmacological Management of Antipsychotics-Induced Weight Gain will be discussed in the following four chapters:

(1) Antipsychotics induced weight gain: Clinical Facts.

  • Which antipsychotics are known for most weight gain among each other?
  • Which antipsychotics have the least risk of significant weight change?
  • Does the duration of antipsychotic use have an impact on weight gain?
  • Will switching antipsychotics to aripiprazole, ziprasidone or amisulpride result in weight loss?
  • How is weight gain in the antipsychotic naive patient subgroup?
  • Which factors are important to consider with weight gain from antipsychotics?

(2) Antipsychotics induced weight gain: Metformin.

(3) Antipsychotics induced weight gain: Samidorphan.

(4) Antipsychotics induced weight gain: Melatonin.

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