Antipsychotic Medications and the Risk of Seizures

Antipsychotic Medications and the Risk of Seizures


This study did a nested case-control analysis to investigate the association between antipsychotic drug use and the development of first-time seizures in patients with schizophrenia, affective disorders, or dementia.



(a) Incidence rate of seizures per 10,000 person-years was:

  • Olanzapine or Quetiapine = 32.6
  • Amisulpride, Aripiprazole, Risperidone, or Sulpiride= 24.1
  • Low-to-Medium Potency Antipsychotic= 49.4
  • Medium-to-High Potency Antipsychotic= 59.1
  • Non-Users of Antipsychotic= 11.7


(b) Patients with dementia had significantly higher incidence rates of first-time seizures compared with patients with affective disorders, irrespective of antipsychotic drug use.


(c) In patients with affective disorders:

  • Current use of medium-to-high potency first-generation antipsychotic drugs was associated with an increased risk of seizures compared with non-use.
  • Use of other antipsychotic drugs was not associated with seizures.


(d) In patients with dementia:

  • Current use of Olanzapine or Quetiapine, Low-to-Medium Potency First-Generation Antipsychotic drugs, and Medium-to-High Potency First-Generation Antipsychotic drugs was associated with an increased risk of seizures compared with non-use.
  • Current use of Amisulpride, Aripiprazole, Risperidone, or Sulpiride was NOT associated with an increased risk of seizures.


Source: CNS Drugs. 2015 Aug 5.

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Dr. Harvinder Singh, M.D. (Admin)

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