Antidepressants use with Hepatitis C?

Which of the following antidepressant have Level 1 evidence for treating depression during Hepatitis C treatment?

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According to this review article published in BMC Gastroenterology: Level 1 Evidence is based on ≥ 2 RCTs (randomized controlled trials) or meta-analysis.

Only Escitalopram currently has Level 1 evidence for treating or preventing depression emerging during Hepatitic C treatment.

Drug Interactions of Escitalopram with Direct-acting antiretrovirals: 

  • No interaction observed with Boceprevir.
  • 35% ↓ escitalopram AUC with Telaprevir: so may need to titrate escitalopram dose according to clinical response.

Academy members will have access to the following chapter:

This chapter will answer the following questions:

  1. Preferred Antidepressant with comorbid Hepatitis C?
  2. Drug interactions between antidepressants and Hepatitis C treatment.
  3. Which antidepressants require dosage adjustment?
  4. Which antidepressants to avoid?
  5. St. John’s Wort use with Hepatitis C?

Antidepressants use with Comorbid Hepatitis C

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