Antidepressants in Bipolar Disorder: Clinical Facts


Q.1: Monotherapy with Antidepressants is not recommended in patient with bipolar disorder. Which antidepressants are preferred in conjunction with mood stabilizer?

  • SSRIs (other than paroxetine)
  • Bupropion


Q.2: What is the recommended duration of treatment with antidepressants in bipolar disorder?

  • Discontinue antidepressants 6–8 weeks after full remission of depression


Q.3: You decided to add antidepressant with mood stabilizer in patient with bipolar disorder. Which antidepressants should be avoided for association with increased risk of manic switch?

  • Tricyclic antidepressants
  • Venlafaxine


Q.4: Antidepressants are not recommended in which subtypes of bipolar disorder?

  • Current mixed episode
  • History of rapid cycling


Source: Bipolar Disorders, 15: 1–44

Please do post your questions or comments below. 

Dr. Harvinder Singh, M.D. (Admin)

Enroll in our online course to have access to all important clinically relevant psychiatry topics in one place.

Related Articles